BRUCEIN D, A NATURALLY OCCURRING TETRACYCLIC TRITERPENE QUASSINOID, INDUCES APOPTOSIS IN PANCREATIC CANCER THROUGH ROS-ASSOCIATED PI3K/AKT SIGNALING PATHWAY

Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities.However, the biologic mechanisms have not been fully explored.In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker cytotoxic effects on GES-1 cells (non-tumorigenic).BD was sh

In this article we assess the distributive objection Dollhouses to the claim that we have associative political obligations.We deploy three kinds of strategy in our response: avoidance, mitigation and confrontation.Avoidance and mitigation are accommodating responses, in which we argue that associative political obligations often need not fall foul

BACKGROUND: ETV6/RUNX1 (E/R) (also known as TEL/AML1) is the most frequent gene fusion in childhood acute lymphoblastic leukemia (ALL) and also most likely the crucial factor for disease initiation; its role in leukemia propagation and maintenance, however, remains largely elusive.To address this issue we performed a shRNA-mediated knock-down (KD)